I would love to play without any sharpening as the game looks so clean however I feel I would be at a huge disadvantage. Details are lost in the fog that are clearly visible with sharpening on and that's not ignoring how much light sharpening adds to inside of Ultra.
Source: https://www.reddit.com/r/EscapefromTarkov/comments/mkug3x/fog_and_the_effects_of_sharpness/