I tried to calculate how many calories a burned playing Dota

Based on a 80KG Male 20-29 years of age playing 1 hour of Dota

we burn around 1,4-2,0 calories per 1,000 mouse clicks

which equals to about 12 calories burned

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moving your arms burns up to 30 calories for an hour

though in dota we mainly move wrist and some portions of the arm

so lets cut the that by half, 5%

which equals to about 16 calories burned

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then you have your basic calorie burn rate which is

your weight in KG/10, i.e 80kg = 80cal burn per hour

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Now a dota game surely increases heart rate, focus etc..

Which leads to about 20% increase to basic calories burned per hour

so in this case 80cal+20% = 96cal

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So lets add all up

12 Calories -mouse clicking

16 calories -moving wrist/hands

96 Calories -Basic burn+ heart rate and vital organs working harder

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Total:

124 Calories burned per hour playing Dota

So you burn 44+ more calories per hour playing dota then for example sitting and watching TV.

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It takes roughly 4hours 20minutes of Dota 2 to burn a Big Mac(Mouse clicks and moving arms taken from studies and applied to an APM of 100+ playing)