I'm sure I'm not the only one at this point, but right now it feels like some quests are straight up impossible to complete simply due to the fact that the keys are too rare and don't show up on the market to buy.
A prime example of this is the Cottage Backdoor key, required for Therapist's quest. Unless you have a Rivals Armband or a Dorms Marked Key, you're pretty much not getting that quest done. I personally have been stuck on the quest since the 4th day of Wipe.
This kind of scenario will get more and more common as expansions and new maps come into the game, as more and more keys will get added in to new rooms and quests. It'll just get more and more difficult to even get simple quests done, like the 206 key quest, 114 key quest, etc etc.
We need a foundation for lockpicking now rather than later, before this inevitably becomes an issue of everyone getting luck-locked out of quest progression.
Source: https://www.reddit.com/r/EscapefromTarkov/comments/wfkz4u/we_need_lockpicking_asap/