The main reason not to use this is the 80% increased damage taken. But what if I told you, you can use it without the penalty?
The reductions from metabolism affect this stim. With max skill levels, the negative part falls off a minimum of 51% faster; boostable by other means, possibly effected by other skills.
If you survive a little over 9 minutes after popping the stim, you get a little over 10 minutes of godly power, only for the price of the easiest to level skill in the game. I'm unsure how low you can get that number, as im not quite sure what the best boosts to metabolism are, or quite how some other skills may effect it, as there may be some that extend the duration of the stim.
Its absolutely insane, don't forget stomach protection, and if possible bring arm protection as well. Works fucking wonders with a zabralo.
Source: https://www.reddit.com/r/EscapefromTarkov/comments/11p6vec/the_terrifying_secret_of_obdolbos_2/